ICP instrument performance is greatly determined by the quality of the aerosol generated by the nebulizers. Performance improves when big drops are removed from the nebulization gas flow, and a spray chamber is located after the nebulizers to achieve this goal. OneNeb Nebulizers generate very fine and reproducible primary aerosols which are mainly formed by droplets with a mean diameter below the cut-off diameters of the spray chambers usually used in ICP liquid-sample introduction systems. As a result, the aerosol lost inside the spray chambers is reduced and sample transport to the plasma is higher than with other pneumatic nebulizers, even at high liquid uptake rates (i.e., 1 mL min-1).